1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
Cialis (tadalafil) can interact with certain foods and beverages, including grapefruit, grapefruit, and grapefruit juice. Food interactions have been shown to have implications for tadalafil absorption and onset of action, especially with high-fat meals.
5.: Though not a direct interaction, combining Cialis with caffeine-containing products might exacerbate side effects like headaches or increase side effect risk. Close monitoring of caffeine levels is recommended.
6.Other antihypertensive medications (e.g.
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inished health conditionAdd to CartThe contents of this site do not replace your regular physician-patient relationship. However, if you are trying to proceed with your prescription, it is important that you let your physician-patient relationship know that you are taking tadalafil. If you have any other personal and medical circumstances, you should know that you are not taking any form of medication. If you do not like the way this website appears on your device, please do not check back recently for new information.
Medically reviewed by Jessica Swirble, PharmDLast updated on March 26, 2025
Drug Information| | |
Tadalafil belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. It is used to treat erectile dysfunction (impotence) by improving blood flow to the penis.
Impotence is a sexual disorder characterized by insufficient blood flow to the penis. This can cause flushing, nausea, and muscle cramps. Tadalafil is usually used once or twice daily as needed, with or without food, to help get and maintain an erection. It does not increase sexual desire. Get Help - MyMedia’s Help Available
Seek medical advice immediately if you experience any unusual symptoms while using tadalafil, including fever, headache, and an erection that lasts more than 4 hours.
Tadalafil is used to treat conditions including:
The use of tadalafil can cause serious side effects. Common side effects include headache, flushing, back pain, muscle pain, and a runny nose. Serious side effects are rare but can include feeling dizzy, lightheadedness, fainting, or, rarely, an erection that lasts longer than 4 hours.
Tadalafil can interact with other medications, causing potentially serious side effects. Tell your healthcare provider if you are taking:
The use of tadalafil may increase your chance of getting:
This is not a complete list of possible side effects. If you have a PDE5 inhibitor, take it twice daily to get the most benefit.
Other side effects that may occur with the use of tadalafil are:
Seek medical attention immediately if you experience:
The risk of priapism isotide is caused by increased blood flow to the penis, which triggers a sudden decrease in blood flow to the penis. The erection lasts more than 4 hours and is usually temporary.
The symptoms of priapism include an erection that lasts more than 4 hours, a sudden decrease or loss of hearing, a sudden loss of vision, or a prolonged erection. If you experience both erectile dysfunction and symptoms of priapism, seek medical attention immediately.
Seek medical attention if you have a heart problem or stroke as a result of the use of tadalafil, or if you have had a heart attack or stroke in the last 6 months.
This drug is not approved for use in children below 18 years.