Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

• Ketoconazole, itraconazole (used to manage fungal infection)
• Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
• Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
• Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
• Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

Rican online pharmacistView whole/businalb/seizeffect/busicalb/seizeffect/

C.

Cialis (tadalafil) can interact with certain foods and beverages, including grapefruit, grapefruit, and grapefruit juice. Food interactions have been shown to have implications for tadalafil absorption and onset of action, especially with high-fat meals.

5.: Though not a direct interaction, combining Cialis with caffeine-containing products might exacerbate side effects like headaches or increase side effect risk. Close monitoring of caffeine levels is recommended.

6.Other antihypertensive medications (e.g.

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The contents of this site do not replace your regular physician-patient relationship. However, if you are trying to proceed with your prescription, it is important that you let your physician-patient relationship know that you are taking tadalafil. If you have any other personal and medical circumstances, you should know that you are not taking any form of medication. If you do not like the way this website appears on your device, please do not check back recently for new information.

Medically reviewed by Jessica Swirble, PharmDLast updated on March 26, 2025

Drug Information| | |

• Brand Name:Cialis, Tadalafil
• Generic Name:Tadalafil Tadalafil
• Uses:Treatment of Erectile dysfunction (ED)
• Drug Class:Cialis - brand-name used on the skin and sometimes in the body
• Availability:Prescription only
• Generic Status:Yes
• Controlled Substance:No

Tadalafil belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. It is used to treat erectile dysfunction (impotence) by improving blood flow to the penis.

Impotence is a sexual disorder characterized by insufficient blood flow to the penis. This can cause flushing, nausea, and muscle cramps. Tadalafil is usually used once or twice daily as needed, with or without food, to help get and maintain an erection. It does not increase sexual desire. Get Help - MyMedia’s Help Available

Seek medical advice immediately if you experience any unusual symptoms while using tadalafil, including fever, headache, and an erection that lasts more than 4 hours.

Tadalafil is used to treat conditions including:

• Erectile Dysfunction (ED): This is a condition where the penis does not get sexually excited for at least 5 consecutive sexual engagements
• Erectile Dysfunction (ED): This is a condition where the penis does not get sexually excited for at least 5 minutes after taking tadalafil

The use of tadalafil can cause serious side effects. Common side effects include headache, flushing, back pain, muscle pain, and a runny nose. Serious side effects are rare but can include feeling dizzy, lightheadedness, fainting, or, rarely, an erection that lasts longer than 4 hours.

Tadalafil can interact with other medications, causing potentially serious side effects. Tell your healthcare provider if you are taking:

• Alpha-blockers (like doxazosin, alfuzosin, or tamsulosin)
• Blood pressure medications (e.g. ramipril, fosamprenil)
• Lipinear medications (e.g. Valdoverse, Valdoverse XR)
• Other medications that cause HIV

The use of tadalafil may increase your chance of getting:

• heart problems
• a heart attack
• stroke
• in connection with stroke or low blood pressure

This is not a complete list of possible side effects. If you have a PDE5 inhibitor, take it twice daily to get the most benefit.

Other side effects that may occur with the use of tadalafil are:

• Constipation
• Dizziness
• Heart palpitations
• Nose and throat problems (e.g. people with or after hard or hard-pliquids ingestion)

Seek medical attention immediately if you experience:

• Fever associated with a type of allergic reaction known as Priapism
• Severe dizziness
• Tremors

The risk of priapism isotide is caused by increased blood flow to the penis, which triggers a sudden decrease in blood flow to the penis. The erection lasts more than 4 hours and is usually temporary.

The symptoms of priapism include an erection that lasts more than 4 hours, a sudden decrease or loss of hearing, a sudden loss of vision, or a prolonged erection. If you experience both erectile dysfunction and symptoms of priapism, seek medical attention immediately.

Seek medical attention if you have a heart problem or stroke as a result of the use of tadalafil, or if you have had a heart attack or stroke in the last 6 months.

This drug is not approved for use in children below 18 years.